A working microlearning sample and L&D approach prepared for the final round.
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PREPARED FOR CRINETICS · APRIL 2026
Selectivity is a scientific story. So is great learning.
A working sample of how I would translate one of PALSONIFY's hardest concepts into a 5-minute microlearning that holds up to a director's TLO/ELO/check audit.
Twenty years across higher education, K-12 systems, and adult learning. The throughline is the same: design that respects the learner's intelligence and proves itself in performance.
PHOTO PLACEHOLDER
Dr. Marie Martin
Drop a 4:5 portrait at assets/marie.jpg to replace this card.
What I bring to the room
I have spent two decades designing learning that has to land the first time. Public school systems do not get to A/B test a unit on civics. Adult learners do not have time to wade through filler. I would bring that same discipline to Crinetics: respect for the learner's time, and content that proves itself in the field.
I treat instructional design as a partnership with science. The MoA is not mine to invent. The patient story is not mine to fictionalize. My craft is to make complex truth land cleanly with the people who need to act on it.
MY LEADERSHIP VALUES
V/01
Community-Based Accountability.
Learning happens in relationship. I design with the people who will use what I build, and I report back to them on what worked. The team is my rubric, not the LMS dashboard. This value carried me through international education reform, school-wide SEL implementation, and every adult-learning project since.
V/02
Problem-Based Learning.
The best learning starts from a real problem the learner already cares about. Not "here are eight facts about acromegaly," but "here is the conversation you are about to walk into with an endocrinologist. What will you do?" PBLWorks/BIE certified, and the orientation has shaped every design I have led, K-12 through adult.
V/03
Human-Centered Design.
Design starts with the human, not the content. Who is the learner? What are they carrying when they sit down? What do they need to walk away holding? The content serves them, never the other way around. In a regulated environment, this is the value that keeps compliance from becoming compliance theater.
V/04
Compliance is part of design.
The science changes. The standards change. The regulations change. In healthcare and life sciences, what was right last year may need updating tomorrow. I design training that holds its shape under shifting requirements: modular pieces that adapt without rebuilding from scratch, claims that can be re-cited cleanly, and a workflow built to absorb new MLR feedback as a feature, not a fire.
02 · How I Work
Eight principles every module passes before it ships.
These are the eight checks I run on my own work before any director ever sees it.
01
Doing over watching
Every 90 seconds of passive content earns its place by being followed by an active doing moment.
02
Topic + So What
Every chunk states the topic AND why it matters. Learners always know why before they invest attention.
03
One TLO, two to three ELOs
Every module has one Terminal Learning Objective and the building steps that get there. Both are measurable, written in Mager format.
04
Check verifies the TLO
The end-of-module check tests the actual TLO, not adjacent knowledge. If the check fails to verify the TLO, the module failed.
05
Performance over recognition
Multiple choice maxes out at 20% of any knowledge check. The other 80% is doing.
06
Spaced reinforcement
A single touch teaches nothing. Day 1, 7, 14, 30 pulses are how content becomes behavior.
07
MLR-friendly modular design
Every claim has a citation. Every visual is brand-compliant. Every script is built to be revised in pieces.
08
IP protection by design
Public AI for public knowledge. Copilot for M365 for internal IP. Synthesia Enterprise for video. Nothing leaves the tenant that should not.
03 · Worked Example
"The Right Door" · 5-minute microlearning
Sample microlearning example, designed using ATD CPTD methodology and Mager performance objectives. Built as an interactive walkthrough so a director can audit the TLO, ELOs, and end-of-module check in one sitting.
PALSONIFY targets one somatostatin receptor with extreme selectivity. That selectivity is what reduces side effects compared with older drugs that hit multiple receptors at once. This 5-minute microlearning teaches one rep how to explain that to one HCP in 30 seconds, without notes.
TLO
By the end of this 5-minute microlearning, the learner will be able to explain to an HCP, in 30 seconds and without notes, why PALSONIFY's SSTR2 selectivity reduces off-target side effects, using the lock-and-key analogy.
ELOs
Identify that there are five somatostatin receptor subtypes (SSTR1 through SSTR5).
Describe the 4,000-fold selectivity figure in plain language.
Connect receptor selectivity to patient tolerability outcomes.
END CHECK
A 30-second self-recorded audio explanation, scored against a 7-criterion rubric, submitted to the manager dashboard. Performance-based, directly verifies the TLO.
STEP 1 / 7 · BASELINE
Where are you right now?
SO WHAT
Self-assessment now will let you see growth at the end. The whole point of this 5 minutes is to take you from "I think I sort of get it" to "I can say it in 30 seconds, in my own voice, to an endocrinologist."
CONFIDENCE CHECK · BASELINE
Drag the glowing dot left or right to rate yourself. 1 means "I have no idea." 5 means "I could explain this on a video call right now." There is no wrong answer. The dot is starting in the middle just so you can see it.
12345
Your rating: 3 / 5
HCP = Healthcare Provider. The doctors, nurse practitioners, physician assistants, RNs, and pharmacists who diagnose acromegaly and prescribe or administer treatment. You will be in front of HCPs every working day.
Type one sentence: if an HCP asked you right now what makes PALSONIFY different from Sandostatin, what would you say?
STEP 2 / 7 · ELO 1 · IDENTIFY THE FIVE DOORS
What ARE these doors?
SO WHAT
Every cell in your body has tiny "locks" built into its surface. The medical word is receptors. Hormones float around the body like keys looking for the right lock to fit into. When a key clicks into a lock, it sends a signal inside the cell that tells the cell what to do: grow, slow down, release a hormone, stop releasing one.
The endocrine system uses a hormone called somatostatin as the body's natural "off switch" for growth hormone. Somatostatin's job is to tell the pituitary to stop making growth hormone. Somatostatin happens to fit into five different lock types in the body, called SSTR1 through SSTR5. That is what the five doors are. Each door controls something different in the body.
Why this matters for your conversation: older drugs (Sandostatin, Somatuline) are like a master key. They knock on all five doors. PALSONIFY is precision-shaped to fit only door #2 (SSTR2). That is the whole story of selectivity. Tap each glowing dot on the image to learn what each door does.
SSTR1
Door 1
Helps slow down cell growth. Found in the pituitary, brain, and lungs.
SSTR2 ★ THE PALSONIFY DOOR
Door 2
Tells the pituitary tumor to stop making growth hormone. This is the door PALSONIFY was designed for.
SSTR3
Door 3
Triggers programmed cell death. Found in the pancreas and brain.
SSTR4
Door 4
Helps regulate inflammation. Found in lungs and brain.
SSTR5
Door 5
Affects insulin release and gallbladder function. When older drugs accidentally knock on this door, this is one source of their side effects.
Tap all 5 hotspots OR click all 5 cards below to continue · 0 / 5 opened
STEP 3 / 7 · ELO 2 · DESCRIBE THE 4,000-FOLD SELECTIVITY
Drag each key to the effect it causes.
SO WHAT
A master key opens every door. The PALSONIFY key only fits one. PALSONIFY is 4,000 times more likely to fit door #2 than any of the other four doors. That is the selectivity figure HCPs care about. Click and drag each key card on the left into the matching effect zone on the right.
DRAG THE KEYS
🗝
KEY A
Older drugs (octreotide, lanreotide)
🗝
KEY B
PALSONIFY (paltusotine)
DROP INTO THE EFFECT
Opens all 5 doors. Helpful for door 2, but causes unintended effects from doors 1, 3, 4, and 5.
Drop a key here
Designed to fit door 2 with 4,000-fold selectivity. Almost no activity at the other doors.
Drop a key here
Drag KEY A and KEY B to their matching effects · 0 / 2 matched
STEP 4 / 7 · ELO 3 · CONNECT
Right door means fewer side effects.
SO WHAT
This is where biology becomes patient experience. When a drug only opens the door it is supposed to open, fewer unintended things happen in the body. This is the line that lands with HCPs.
Write the lock-and-key explanation in your own words, as if you were saying it to an endocrinologist. Two to three sentences. Use the words "five receptors," "selectivity," and "fewer side effects" somewhere in your answer.
Click to reveal a model answer (after you write yours)
The body has five somatostatin receptors. Older drugs hit all five at once, which controls the disease but causes side effects from the four receptors we did not need to touch. PALSONIFY is designed to fit only the second receptor with 4,000-fold selectivity, which means fewer side effects from the receptors that were never the target.
STEP 5 / 7 · THE CHECK · VERIFIES TLO
Now say it out loud.
SO WHAT · THIS IS THE CHECK
The TLO said you would be able to explain this in 30 seconds, without notes, using the lock-and-key analogy. This is where you prove it. Record yourself. Listen back. Self-rate against the rubric. Re-record if you need to.
QUICK STUDY · BEFORE YOU RECORD
Three facts to remember from ELO 1 and ELO 2:
1
Five doors. The body has 5 somatostatin receptors (SSTR1 through SSTR5). Each one controls something different.
2
4,000-fold selectivity. PALSONIFY is 4,000 times more likely to fit door #2 (SSTR2) than any other door. Older drugs hit all five.
3
Right door = fewer side effects. Selectivity is what makes the patient experience different. That is the point that lands with HCPs.
No mic available? Type your 30-second explanation here instead. Self-rate against the rubric on the next step the same way.
STEP 6 / 7 · SELF-RATE
How did you do?
SO WHAT
Listen back to your recording. Check each criterion you met. A passing recording hits at least 6 of 7. If you scored fewer, go back to the recorder and try again before submitting to your manager.
The 7-criterion rubric
Score: 0 / 7 · Aim for at least 6.
RESPONSIBLE AI · ATTESTATION
Before you submit, confirm one more thing.
Pharma L&D is a regulated environment. AI-generated content in training is a growing area of scrutiny. This attestation is separate from the 7-point rubric on purpose. It is not about your performance. It is about the integrity of the recording.
STEP 7 / 7 · CLOSE
Where are you now?
SO WHAT
Compare your starting confidence to where you are now. Then commit to one specific HCP conversation this week where you will use the lock-and-key explanation.
CONFIDENCE CHECK · AFTER THE LESSON
Drag the glowing dot left or right to rate yourself now. Same scale as before. We will show you the difference between your starting score and your ending score.
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Your rating: 3 / 5
Commit to one HCP conversation this week where you will use the lock-and-key explanation. Type the HCP's role (do not include identifying patient or HCP info), and one sentence on the moment you will use it.
CHECK COMPLETE
You just did the thing.
Your commitment is captured for your manager dashboard. They will check in with you at your next 1:1 to ask how the conversation went. That is the spaced reinforcement loop that turns one microlearning into actual behavior change.
04 · The Full Pathway
The pathway is the spacing, not the modules.
Each row is its own microlearning with its own TLO and ELOs. The pathway adds spacing and reinforcement, not extra content inside any single asset. Click any row to expand the ELOs.
05 · The First 90 Days
Listen first. Build one perfect thing. Scale.
I will not propose a strategy until I have inventoried the systems, walked through the MLR process end to end, and met every stakeholder L&D depends on.
30
DISCOVERY
Listen, map, ship one small thing.
Onboarding, system access, stakeholder listening tour, MLR walkthrough, content audit. End of month: one quick-win asset shipped through MLR.
Systems inventory v1
Stakeholder map and themes
Content audit summary
One asset MLR-approved and shipped
60
PILOT
Build one perfect microlearning end to end.
Lock the pathway architecture. Build the worked example. Validate the MLR workflow. Stand up the measurement framework.
"The Right Door" published to LMS QA
Locked pathway architecture
MLR workflow log with patterns
Measurement framework documented
90
SCALE
Build the rest. Document. Hand off.
Build the remaining microlearnings in two-week sprints. Stand up Day 7, 14, 30, 60 reinforcement pulses. Document the production playbook as the leave-behind.
